Reduction and Refinement in Experimental Design and Methodology. Research and Development of Drugs

Coordinación

Module coordinator:
Joan Antoni Fernandez-Blanco.
Barcelona Biomedical Research Park (PRBB), Spain

Teaching staff: 

Julio Alvarez 

Data Sciences International, Belgium

Elena Abellán Rubio 

Microsurgery Unit, Centro de Cirugía de Mínima Invasión Jesús Usón, Cáceres, Spain

Ignacio Álvarez 

Faculty of Veterinary Medicine, Universidad Complutense, Madrid, Spain

Sandra Barbosa Pérez

Integrated Laboratory Animal Services (SIAL), Universitat Autònoma de Barcelona, Barcelona, Spain

Manuel Berdoy 

Oxford University, UK

Marco Boscaro 

Data Sciences International, Italy

Juan Antonio Cámara 

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

Marielle Esteves Coelho

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

Laia Foradada

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

Laura Fresno

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

César Galo García Fontecha 

Hospital Sant Joan de Deu, Spain

Marta Giral

Almirall, Barcelona, Spain

Fran Gomez 

Anapath Research, Spain

Elena Jiménez Xarrié

Stroke Unit, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain

Silvia Lope

Service of MRI, Universitat Autònoma de Barcelona, Barcelona, Spain

Fernando de Mora

Department of Pharmacology, Universitat Autònoma de Barcelona, Barcelona, Spain

Carmen Navarro

Service of Quality in Research, Universitat de Barcelona, Spain

Sonia Nuncio

Charles River Laboratories España, Sant Cugat del Vallès, Spain

Anna Pujol Esclusa

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

Kate Read

Covance Laboratory Limited, UK

Merel Ritskes-Hoitinga

SYRCLE, Radboud University Medical Center, Nijmegen, The Netherlands

Daniel Ruiz 

Trinity College, Dublin, Ireland

David Sabaté

Hipra Laboratories, Amer, Spain

Beatriz Salinas Rodriguez

Instituto de Investigación Sanitaria Gregorio Marañon, Madrid , Spain

Laura Santos

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

Anna Server Salvà

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

Marcello Tontodonati 

Glaxo Hertfordshire, UK

Adrià Urbano Sánchez

Department of Pharmacology, Universitat Autònoma de Barcelona, Barcelona, Spain

Javier Vela Gonzalez

Microsurgery Unit, Centro de Cirugía de Mínima Invasión Jesús Usón, Cáceres, Spain

Kim Wever

SYRCLE, Radboud University Medical Center, Nijmegen, The Netherlands

Duration of the module: 
12 ECTS (80 attendance hours)
Cost: 

€ 3,200

Course dates: 

1 October -15 December, 2024.

Attendance dates: to be defined

Descripcion

This course provides the practical and theoretical knowledge and skills regarding experimental design and methodology required by designated veterinarians and other onsite personnel responsible for the welfare and care of laboratory animals in the conduct of experimental procedures.

This course covers the most important aspects in relation to the reduction in the number of animals used in research, experimental design, literature searches and presentation of results. It also deals with refinement through the study of the main non-invasive and minimally invasive techniques and refinement in surgical techniques. The module also provides an overview of the strategy and processes required in research and drug development.

The content of this course also complies with the training requirements set out in European Directive EU63/2010 developed by the European Commission in respect of the following modules: 10. Design of procedures and projects (level 1), 11. Design of procedures and projects (level 2), 22. Principles of surgery and 51. Information provision and retrieval. For details, see: https://ec.europa.eu/environment/chemicals/lab_animals/pdf/Endorsed_E-T.pdf

Syllabus: 

Topic 1: Reduction

1.1 Experimental design
1.2 Systematic Reviews 
1.3 Bias analysis

Topic 2. Refinement: 

2.1  Asepsis and preparation for surgery 
2.2  Pre, peri and post-operative care
2.3  Microsurgery. Vascular techniques
2.4   Minimally Invasive Surgery
2.5  Sampling techniques
2.6 Recording of physiological parameters by minimally invasive techniques 
2.7 Non invasive techniques: MRI, PET, ecography, biolluminiscence, Micro-CT 

Topic 3. Drug development. Experimental procedures uner regulation

3.1 Drug development and drug efficacy
3.2 Development of veterinary drugs
3.3 Drug development: Safety and Toxicology
3.4 Biologicals: immunogenicity and immunotoxicity 
3.5 Translational research
3.6 Quality standards: Good Laboratory Practice and consistency in conducting scientific procedures and correct handling, storing, recording, and ensuring traceability of samples

Registration or more information:

Tel:(+34) 935 811 848
e-mail: pg.animals.laboratori@uab.cat