Reduction and Refinement in Experimental Design and Methodology. Research and Development of Drugs

Coordinación

Module coordinator:
Joan Antoni Fernandez-Blanco DVM, PhD.

Faculty of Veterinary Medicine, Universitat Autonoma de Barcelona, Spain

Teaching staff: 

Elena Abellán Rubio 

Microsurgery Unit, Centro de Cirugía de Mínima Invasión Jesús Usón, Cáceres, Spain

Ignacio Álvarez 

Faculty of Veterinary Medicine, Universidad Complutense, Madrid, Spain

Alberto Ballestín Rodríguez 

Microsurgery Unit, Centro de Cirugía de Mínima Invasión Jesús Usón, Cáceres, Spain

Sandra Barbosa Pérez

Integrated Laboratory Animal Services (SIAL), Universitat Autònoma de Barcelona, Barcelona, Spain

Manuel Berdoy 

Oxford University, UK

Marco Boscaro 

Data Sciences International, Italy

Alan Broadmeadow

Envigo, UK

Juan Antonio Cámara 

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

Marielle Esteves Coelho

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

Félix García Arnás

Department of Veterinary Medicine, Faculty of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

César Galo García Fontecha 

Vall d’Hebrón Hospital, Barcelona, Spain

Marta Giral

Almirall, Barcelona, Spain

Silvia Lope

Service of MRI, Universitat Autònoma de Barcelona, Barcelona, Spain

Erica López 

Faculty of Medicine, University of Marseille, France.

Pere Losada Fernández

Department of Pharmacology, Universitat Autònoma de Barcelona, Barcelona, Spain

Montse Miralpeix

Galapagos NV, Mechelen, Belgium

Xavier Moll 

Department of Veterinary Medicine, Faculty of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

Fernando de Mora

Department of Pharmacology, Universitat Autònoma de Barcelona, Barcelona, Spain

Francisca Mulero

Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Merel Ritskes-Hoitinga

SYRCLE, Radboud University Medical Center, Nijmegen, The Netherlands.

Marta Rosal

Vall d’Hebron Research Institute (VHIR), Barcelona, Spain.

David Sabaté

Hipra Laboratories, Amer, Spain

Maria Esther Sánchez Saguer

Quality Assurance Unit, Universitat Autònoma de Barcelona, Barcelona, Spain.

Rui Simoes

Universitat de Barcelona, Sapin

Adrià Urbano Sánchez

Department of Pharmacology, Universitat Autònoma de Barcelona, Barcelona, Spain

Rob de Vries

SYRCLE, Radboud University Medical Center, Nijmegen, The Netherlands

Duration of the module: 
12 ECTS (80 attendance hours)
Cost: 

2.590 €

Course dates: 

1 October -15 December, 2017.

Attendance dates: October 23 to 27 and November 13 to 17, 2017

Descripcion

This module provides the practical and theoretical knowledge and skills regarding experimental design and methodology required by designated veterinarians and other onsite personnel responsible for the welfare and care of laboratory animals in the conduct of experimental procedures.

This module covers the most important aspects in relation to the reduction in the number of animals used in research, experimental design, literature searches and presentation of results. It also deals with refinement through the study of the main non-invasive and minimally invasive techniques and refinement in surgical techniques. The module also provides an overview of the strategy and processes required in research and drug development.

The content of this module also complies with the training requirements set out in Spanish Royal Decree RD53/2013 and European Directive EU63/2010 developed by the European Commission in respect of the following modules: Design of procedures and projects (level 1), Principles of surgery and information provision and retrieval.

For details, see: http://ec.europa.eu/environment/chemicals/lab_animals/pdf/Endorsed_E-T.pdf

Syllabus: 

Topic 1: Reduction

1.1 Experimental design
1.2 Bibliographic Searches 
1.3 Systematic searches and ARRIVE guidelines

Topic 2. Refinement: 

2.1  Asepsis and preparation for surgery 
2.2  Pre, peri and post-operative care
2.3  Microsurgery. Vascular techniques
2.4   Minimally Invasive Surgery
2.5  Sampling techniques
2.6 Recording of physiological parameters by minimally invasive techniques 
2.7 Non invasive techniques: MRI, PET, ecography, biolluminiscence, Micro-CT 

Topic 3. Drug development. Experimental procedures uner regulation

3.1 Drug development phases
3.2 Drug Eficacy 
3.3 Safety Pharmacology: cardiovascular, respiratory and nervous
3.4 Toxicology 
3.5 Clinical assays
3.6 Clinical assays of veterinary drugs
3.7 Quality standards: Good Laboratory Practice

Registration or more information:

Tel:(+34) 935 811 848
e-mail: pg.animals.laboratori@uab.cat