Genetics of Laboratory Animals and Experimental Models

Coordinación

Module coordinators:
Belen Pintado
Centro Nacional de Biotcnología, Madrid.

Agustín Casadesús
Envigo CRS SA Spain

Teaching staff: 

Antonio Armario
Universitat Autònoma de Barcelona

Fernando Benavides
MD Anderson Cancer Center

James Bussell
Sanger Institute, Reino Unido

Agustí Casadesús
Envigo CRS SA Spain.

Graziano Fiorito
Stazione Zoologica Anton Dohrn, Napoli, Italy

Jean Jaubert
Institute Pasteur, Paris

Lluís Montoliu
CNB-CSIC, Madrid

Teresa Paramio
Universitat Autonoma de Barcelona

Belén Pintado
CNB, Madrid.

Jordi Polo
Envigo CRS SA, Barcelona.

Anna Pujol
CBATEG, Barcelona.

Marina Raya
Centro de Medicina Regenerativa. Parc de Recerca Biomèdica de Barcelona.

Montserrat Rigol
IDIBAPS, Barcelona

Jesús Ruberte
Universitat Autònoma de Barcelona

Laura Soucek
Fundació VHIO, Barcelona

Rosa Torres
Leitat, Barcelona

Graham Tobin
Envigo RMS, UK

David P Wolfer
Neuroscience Center, Zurich Suiza

Sergi Xanxo
Envigo CRS SA Spain .

English for lectures and course materials. For practical sessions groups for both English and Spanish speakers

Duration of the module: 
15 ECTS, (88 attendance hours)
Cost: 

2,970 (may be made in two instalments of €1,485)

Course dates: 

15 February -15 May 2016

Attendance dates: April 4-9 & April 25-30, 2016

Descripcion

This module provides the practical and theoretical knowledge and skills regarding genetics and experimental models required by designated veterinarians and other onsite personnel responsible for the welfare and care of laboratory animals in the conduct of experimental procedures.

The module consists of two parts. The experimental models component provides extensive knowledge of different experimental animal models in different research areas. The genetic component explores models of genetically modified animals, their production, maintenance and the implications of their use. 

This module also provides practical training in relation to animal biology, euthanasia and minimally invasive methods.

The content of this module also complies with the training requirements set out in Spanish Royal Decree RD53/2013 and European Directive EU63/2010 developed by the European Commission in respect of the following modules:

Basic and appropriate biology (theory); Basic and appropriate biology (practical), Humane methods of killing (skills), Minimally invasive procedures  without anaesthesia (theory), Minimally invasive techniques without anaesthesia (skills). For details, see: http://ec.europa.eu/environment/chemicals/lab_animals/pdf/Endorsed_E-T.pdf

Syllabus: 

Topic 1.Genetics, genetic control and genetically modified rodents. 

1.1.       Genetics applied to experimental animals. 
1.2.       Choice of experimental model based on genetic characteristics. 
1.3.       Types of lines genetically standardized mice. 
1.4.       Genetic control of rodents. 
1.5.       Production of genetically modified animals. Reproductive physiology.  Superovulation. 
1.6.       Health rederivation. Transfer and freezing of embryos. Legislation on GMO's. 
1.7.       Management of colonies of genetically modified animals. 
1.8.       Phenotyping. 
1.9.       Practical sessions: 
1.9.1.    Embryo collection from a single cell. 
1.9.2.    Vasectomy 
1.9.3.    Freezing. 
1.9.4.    FIV and microinjection techniques. 
1.9.5.    Genotyping 
1.9.6.    Phenotyping

Topic 2. Non-rodent genetically modified models 

2.1        Fish
2.2.       Large animals

Topic 3 Selection of experimental model according to type of research. 

3.1.      Experimental models in immunology.
3.2.      Experimental models in infectious diseases.

3.3.      Experimental models in oncology.

3.4.      Experimental models in pharmacology, toxicology and safety.

3.5       Experimnental models in diabetes and metabolic diseases.

3.6       Experimental models in neurodegenerative diseases

3.7       Experimental models in cardiovascular diseases

3.8       Experimental models in Reproduction

 

Topic 4. Nutrition and its influence on research

Topic 5. Biology, management and care guidelines in cephalopods

Topic 6. Practical sessions on  management, administration and taking samples in the main species of experimental animals: rodents, rabbits, dogs, pigs, ruminants, nonhuman primates, birds, fish, amphibians and cephalopods.

Registration or more information:

Tel:(+34) 935 811 848
e-mail: pg.animals.laboratori@uab.cat